by Floris-Jan Zuure
April 23, 2025

EXOSOMES AND REGENERATIVE SKINCARE

EXOSOMES AND REGENERATIVE SKINCARE

INTRODUCTION: WHAT IF YOUR SKIN COULD COMMUNICATE BETTER?

Your skin isn’t just a surface. It’s a dynamic, responsive organ. And communication is key. In the world of regenerative skincare, exosomes are now leading the conversation.

These microscopic messengers work deep within the skin to enhance cellular repair, calm inflammation, and trigger long-term rejuvenation. At Salon d’Homme, we integrate the latest generation of synthetic exosome complexes into our newest treatments to help your skin work smarter, not harder.

Regenerative skincare focuses on stimulating the skin’s own repair systems using biological signals instead of aggressive damage (from devices or intense products). We’re constantly searching for less invasive ways to activate this natural intelligence. At Salon d’Homme, that principle shapes everything we do.

WHAT ARE EXOSOMES?

Think of your skin cells as employees in a highly organised company. The stem cell is like the head office, making strategic decisions about repair and renewal.

Exosomes? They’re the high-performing managers and express couriers, carrying precise instructions and resources to the teams (your skin cells) who get the job done.

They're microscopic messengers released by cells, carrying vital biological information that helps other cells repair, regenerate, or rebalance. Originally isolated from a specific type of stem cell involved in tissue regeneration, these exosomes play a key role in restoring skin, collagen, blood vessels and more.

THE POWER OF MSC-DERIVED EXOSOMES

The most effective exosomes for skin regeneration come from mesenchymal stem cells (MSCs). These are multipotent stem cells, meaning they can develop into different types of tissue. They come from the mesoderm, responsible for many of the body’s repair and support systems, including:

  • Skin and connective tissue

  • Collagen and extracellular matrix

  • Blood vessels (vascular structures)

  • Muscle and soft tissue

Exosomes from MSCs carry a rich cocktail of growth factors, peptides, and anti-inflammatory signals that directly support these systems. They naturally carry a potent mix of growth factors, peptides, and regulatory molecules that support regeneration and calm inflammation, all delivered with cellular precision. 

WHY EXOSOMES OUTPERFORM OTHER SOURCES

Earlier generations of exosome-based skincare often used ingredients derived from plant stem cells (like rose) or probiotics (like lactobacillus). While these can offer some antioxidant or soothing benefits, their biological messages simply don’t match what human skin cells understand.

Think of it this way:

A plant-derived exosome is like trying to send a voice memo in French to someone who only speaks Dutch; the message doesn’t land.

Human skin cells rely on very specific signalling to trigger regeneration, and only exosomes derived from human-compatible sources speak that same cellular “language.” That’s why plant or probiotic versions are often less potent or predictable in their results.

Human-derived MSC exosomes were once the gold standard, but ethical concerns and changing regulations led to the development of biomimetic exosomes: lab-designed to replicate the molecular profile of these powerful, skin-compatible messengers. They offer the same regenerative potential, but in a safer, more controlled way.

Our exosome complex is enriched with regenerative actives, including peptides and Salmon DNA (PDRN). A powerful molecule known to stimulate skin repair and boost natural cell regeneration

EXOSOME REGENERATION TREATMENT: FULL-SPECTRUM SKIN REGENERATION

At Salon d’Homme, we’ve developed a treatment that brings together the best of science, advanced skin therapy, and intelligent product technology:

  • AI-powered skin analysis to tailor your treatment
  • Lymphatic drainage to detoxify and enhance recovery
  • Microneedling using a powerful regenerative exosome complex (rich in peptides and PDRN)
  • Low molecular weight hyaluronic acid (Forlle’d - Hyalogy Lift Mask) to deeply hydrate and reinforce the skin barrier
  • Neck and shoulder massage to relax and restore balance

This treatment is our most complete skin regeneration protocol. Refined, multi-layered, and driven by results. It’s ideal for those seeking visible improvements in skin texture, tone, and resilience, without unnecessary downtime.

That said, it’s important to understand that your skin reflects more than just the treatment protocol. Lifestyle factors like nutrition, sleep, stress, alcohol, nicotine, and sun exposure have a significant impact on the way your skin behaves and responds.

While results from this protocol have been highly promising, true transformation comes from consistency both in-clinic and at home.

REFERENCES

  1. Lener T, et al. (2015). Applying extracellular vesicles based therapeutics in clinical trials. Journal of Extracellular Vesicles.

  2. Kim H, et al. (2019). Mesenchymal stem cell-derived exosomes for skin rejuvenation. Stem Cell Research & Therapy.

  3. Wang L, et al. (2020). Exosomes in skin wound healing. Frontiers in Cell and Developmental Biology.

  4. EU Regulation 2017/745 (updated 2023) on human-derived biological substances.